apalutamide will lessen the level or result of diazepam by affecting hepatic enzyme CYP2C19 metabolism. Avoid or Use Alternate Drug. Coadministration of apalutamide, a robust CYP2C19 inducer, with medicines which can be CYP2C19 substrates may end up in reduce exposure to those drugs.ceritinib will boost the level or effect of diazepam by impacting